Small molecules which reverse ADAM17 Conditional KO in keratinocytes
Canned Analysis
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General Information
AccessionDCA00023172
TitleSmall molecules which reverse ADAM17 Conditional KO in keratinocytes
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ADAM17 Conditional KO in keratinocytes in the Keratinocytes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21402e467bea600fbaa4a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorCarolet
CREEDS IDgene:3100
Cell TypeKeratinocytes
Gene Symbol (human)ADAM17
Gene Symbol (mouse)Adam17
Organismmouse
Perturbation TypeConditional KO in keratinocytes
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM950400, GSM950402
Perturbed SamplesGSM950401, GSM950403
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38830
Gene Expression Omnibus
Conditional keratinocyte-specific ADAM17 knockout in mice alters skin homeostasis
7
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