Small molecules which reverse CXCR4 KO
Canned Analysis
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General Information
AccessionDCA00023174
TitleSmall molecules which reverse CXCR4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CXCR4 KO in the cerebellum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d213efe467bea600fbaa42
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:3102
Cell Typecerebellum
Gene Symbol (human)CXCR4
Gene Symbol (mouse)Cxcr4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1184633, GSM1184634, GSM1184635, GSM1184636, GSM1184637, GSM1184638, GSM1184639, GSM1184640
Perturbed SamplesGSM1184641, GSM1184642, GSM1184643, GSM1184644, GSM1184645, GSM1184646, GSM1184647
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48788
Gene Expression Omnibus
Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice
7
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