Small molecules which reverse IFNL3 mutant (SNP polymorphism)
Canned Analysis
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General Information
AccessionDCA00023188
TitleSmall molecules which reverse IFNL3 mutant (SNP polymorphism)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IFNL3 mutant (SNP polymorphism) in the Analysis of resected liver from hepatocellular carcinoma (HCC) patients with chronic hepatitis C (CHC) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d225e9e467bea600fbb1f2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:3109
Cell TypeAnalysis of resected liver from hepatocellular carcinoma (HCC) patients with chronic hepatitis C (CHC)
Gene Symbol (human)IFNL3
Gene Symbol (mouse)Ifnl3
Organismhuman
Perturbation Typemutant (SNP polymorphism)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1024521, GSM1024522, GSM1024523, GSM1024524, GSM1024525, GSM1024526, GSM1024527, GSM1024528, GSM1024529, GSM1024530, GSM1024531, GSM1024532, GSM1024533, GSM1024534, GSM1024535, GSM1024536, GSM1024537, GSM1024538, GSM1024539, GSM1024540
Perturbed SamplesGSM1024541, GSM1024542, GSM1024543, GSM1024544, GSM1024545, GSM1024546, GSM1024547, GSM1024548, GSM1024549, GSM1024550, GSM1024551, GSM1024552, GSM1024553, GSM1024554, GSM1024555, GSM1024556, GSM1024557, GSM1024558, GSM1024559, GSM1024560
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41804
Gene Expression Omnibus
IL-28B polymorphism effect on hepatitis C virus-related hepatocellular carcinoma: resected liver
21
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