Small molecules which mimic PPARGC1A KO
Canned Analysis
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General Information
AccessionDCA00023233
TitleSmall molecules which mimic PPARGC1A KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PPARGC1A KO in the brain striatum cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fb21e467bea600fb9f56
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorantons
CREEDS IDgene:326
Cell Typebrain striatum
Gene Symbol (human)PPARGC1A
Gene Symbol (mouse)Ppargc1a
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM135225, GSM135226, GSM135227
Perturbed SamplesGSM135217, GSM135219, GSM135221
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5786
Gene Expression Omnibus
PGC-1alpha transcriptional coactivator null mutation effect on the brain striatum
12
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