Small molecules which reverse BTK Missense mutation R28C
Canned Analysis
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General Information
AccessionDCA00023240
TitleSmall molecules which reverse BTK Missense mutation R28C
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by BTK Missense mutation R28C in the splenic B cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21960e467bea600fbaca6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:976
Cell Typesplenic B cells
Gene Symbol (human)BTK
Gene Symbol (mouse)Btk
Organismmouse
Perturbation TypeMissense mutation R28C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM61837, GSM61838
Perturbed SamplesGSM61839, GSM61840
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2826
Gene Expression Omnibus
Bruton's tyrosine kinase mutant models of X-linked agammaglobulinemia
14
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