Small molecules which reverse GATA4 KO
Canned Analysis
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General Information
AccessionDCA00023270
TitleSmall molecules which reverse GATA4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by GATA4 KO in the Adult heart during pressure overload cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2025ae467bea600fba286
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:356
Cell TypeAdult heart during pressure overload
Gene Symbol (human)GATA4
Gene Symbol (mouse)Gata4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1262797, GSM1262798
Perturbed SamplesGSM1262801, GSM1262802, GSM1262803
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52317
Gene Expression Omnibus
Cardiomyocyte-specific Gata-4 or Gata-6 knockout effect on adult heart during pressure overload
14
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