Small molecules which mimic HDAC6 KO
Canned Analysis
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General Information
AccessionDCA00023337
TitleSmall molecules which mimic HDAC6 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by HDAC6 KO in the Foxp3(+) Tregs cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20a6ce467bea600fba610
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:559
Cell TypeFoxp3(+) Tregs
Gene Symbol (human)HDAC6
Gene Symbol (mouse)Hdac6
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM688863, GSM688864, GSM688865
Perturbed SamplesGSM688866, GSM688867, GSM688868
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE27896
Gene Expression Omnibus
Histone/protein deacetylase (HDAC) 6-deficient CD4+CD25+ T-regulatory cells
12
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