Small molecules which reverse PRKAG3 Mutation (R225Q)
Canned Analysis
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General Information
AccessionDCA00023350
TitleSmall molecules which reverse PRKAG3 Mutation (R225Q)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PRKAG3 Mutation (R225Q) in the Skeletal muscle cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23256e467bea600fbb76e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsara
CREEDS IDgene:417
Cell TypeSkeletal muscle
Gene Symbol (human)PRKAG3
Gene Symbol (mouse)Prkag3
Organismmouse
Perturbation TypeMutation (R225Q)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM92993, GSM92994, GSM93002, GSM93003, GSM93004, GSM93005, GSM93235, GSM93236, GSM93237, GSM93238, GSM93239, GSM93240
Perturbed SamplesGSM93229, GSM93230, GSM93231, GSM93232, GSM93233, GSM93234
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4067
Gene Expression Omnibus
AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates
7
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