Small molecules which mimic SIRT3 KO
Canned Analysis
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General Information
AccessionDCA00023351
TitleSmall molecules which mimic SIRT3 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SIRT3 KO in the BROWN ADIPOSE TISSUE cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22888e467bea600fbb31c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:42
Cell TypeBROWN ADIPOSE TISSUE
Gene Symbol (human)SIRT3
Gene Symbol (mouse)Sirt3
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM675147, GSM675148, GSM675149, GSM675150, GSM675151
Perturbed SamplesGSM675152, GSM675153, GSM675154, GSM675155, GSM675156
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE27309
Gene Expression Omnibus
SIRT3 knockout effect on brown adipose tissue
7
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