Small molecules which mimic SIRT3 KO
Canned Analysis
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General Information
AccessionDCA00023375
TitleSmall molecules which mimic SIRT3 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SIRT3 KO in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20162e467bea600fba216
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorzero323
CREEDS IDgene:443
Cell Typeliver
Gene Symbol (human)SIRT3
Gene Symbol (mouse)Sirt3
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM758179, GSM758180, GSM758181
Perturbed SamplesGSM758182, GSM758183, GSM758184
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE30552
Gene Expression Omnibus
SIRT3 deficient liver response to a high fat diet
14
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