Small molecules which reverse DOT1L DELETION
Canned Analysis
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General Information
AccessionDCA00023390
TitleSmall molecules which reverse DOT1L DELETION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by DOT1L DELETION in the AF9 - Mixed Lineage Leukemia (MLL) cells - 3 days cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1faf6e467bea600fb9f44
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:453
Cell TypeAF9 - Mixed Lineage Leukemia (MLL) cells - 3 days
Gene Symbol (human)DOT1L
Gene Symbol (mouse)Dot1l
Organismmouse
Perturbation TypeDELETION
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM636703, GSM636704, GSM636705, GSM636706
Perturbed SamplesGSM636698, GSM636699, GSM636700, GSM636701, GSM636702
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25911
Gene Expression Omnibus
Histone methyltransferase H3K79 Dot1l deletion effect on MLL-AF9 leukemia cells: time course
21
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