Small molecules which mimic DOT1L DELETION
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00023393
TitleSmall molecules which mimic DOT1L DELETION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by DOT1L DELETION in the AF9 - Mixed Lineage Leukemia (MLL) cells - 7 days cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fb2ae467bea600fb9f5a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:455
Cell TypeAF9 - Mixed Lineage Leukemia (MLL) cells - 7 days
Gene Symbol (human)DOT1L
Gene Symbol (mouse)Dot1l
Organismmouse
Perturbation TypeDELETION
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM636720, GSM636721, GSM636722, GSM636723
Perturbed SamplesGSM636717, GSM636718, GSM636719
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25911
Gene Expression Omnibus
Histone methyltransferase H3K79 Dot1l deletion effect on MLL-AF9 leukemia cells: time course
21
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.