Small molecules which reverse TP53 DEPLETION
Canned Analysis
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General Information
AccessionDCA00023418
TitleSmall molecules which reverse TP53 DEPLETION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TP53 DEPLETION in the MDA-MB-231 breast cancer cells (depleted of MUTANT-p53) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23d26e467bea600fbbc34
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:478
Cell TypeMDA-MB-231 breast cancer cells (depleted of MUTANT-p53)
Gene Symbol (human)TP53
Gene Symbol (mouse)Trp53
Organismhuman
Perturbation TypeDEPLETION
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM645041, GSM645042, GSM645043
Perturbed SamplesGSM645044, GSM645045, GSM645046
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26262
Gene Expression Omnibus
Mutant-p53 and Pin1 depleted MDA-MB-231 breast cancer cells
14
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