Small molecules which reverse ESR1 KD
Canned Analysis
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General Information
AccessionDCA00023420
TitleSmall molecules which reverse ESR1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ESR1 KD in the MCF7 estrogen-sensitive breast cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23d2fe467bea600fbbc38
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:479
Cell TypeMCF7 estrogen-sensitive breast cancer cells
Gene Symbol (human)ESR1
Gene Symbol (mouse)Esr1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM645710, GSM645711, GSM645718, GSM645719
Perturbed SamplesGSM645716, GSM645717
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE26298
Gene Expression Omnibus
Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells
21
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