Small molecules which mimic GSK3B INHIBITION
Canned Analysis
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General Information
AccessionDCA00023429
TitleSmall molecules which mimic GSK3B INHIBITION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by GSK3B INHIBITION in the MLL leukemia cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21639e467bea600fbab40
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:486
Cell TypeMLL leukemia cells
Gene Symbol (human)GSK3B
Gene Symbol (mouse)Gsk3b
Organismhuman
Perturbation TypeINHIBITION
None{u'vals': [0.0726540823434, -0.0659758692681, 0.0584637188453, -0.0527163053885, 0.0506732413055, -0.0495627415916, -0.0477003636965, -0.0471202400544, -0.0437635572866, 0.0435387058839, 0.0434779096386, 0.0425527849247, 0.0421681965864, 0.0406952036756,
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM492838, GSM492846
Perturbed SamplesGSM492847, GSM492848, GSM492849
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE19736
Gene Expression Omnibus
Glycogen synthase kinase 3 inhibitor effect on MLL leukemia cells
12
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