Small molecules which reverse PPARA agonist activation
Canned Analysis
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General Information
AccessionDCA00023454
TitleSmall molecules which reverse PPARA agonist activation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PPARA agonist activation in the Isolated hepatocytes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ef7fe467bea600fb9a80
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatordsurujon
CREEDS IDgene:501
Cell TypeIsolated hepatocytes
Gene Symbol (human)PPARA
Gene Symbol (mouse)Ppara
Organismhuman
Perturbation Typeagonist activation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM432140, GSM432142, GSM432144, GSM432146, GSM432148, GSM432150, GSM432152, GSM432154, GSM432156, GSM432158, GSM432160, GSM432162
Perturbed SamplesGSM432139, GSM432141, GSM432143, GSM432145, GSM432147, GSM432149, GSM432151, GSM432153, GSM432155, GSM432157, GSM432159, GSM432161
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17251
Gene Expression Omnibus
Comparative analysis of gene regulation by the transcription factor PPAR_human
7
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