Small molecules which reverse AKT1 KO
Canned Analysis
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General Information
AccessionDCA00023460
TitleSmall molecules which reverse AKT1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by AKT1 KO in the heart cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1efa0e467bea600fb9a90
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatordsurujon
CREEDS IDgene:506
Cell Typeheart
Gene Symbol (human)AKT1
Gene Symbol (mouse)Akt1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1558461, GSM1558462, GSM1558463
Perturbed SamplesGSM1558464, GSM1558465, GSM1558466
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE63848
Gene Expression Omnibus
Akt-Induced Mitochondrial Dysfunction in the Heart
7
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