Small molecules which reverse BRCA1 DEPLETION
Canned Analysis
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General Information
AccessionDCA00023482
TitleSmall molecules which reverse BRCA1 DEPLETION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by BRCA1 DEPLETION in the Hela cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23094e467bea600fbb6aa
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:65
Cell TypeHela
Gene Symbol (human)BRCA1
Gene Symbol (mouse)Brca1
Organismhuman
Perturbation TypeDEPLETION
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM554070, GSM554072, GSM554074
Perturbed SamplesGSM554071, GSM554073, GSM554075
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE22259
Gene Expression Omnibus
BRCA1 depletion effect on HeLa cells
14
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