Small molecules which mimic AIRE KO
Canned Analysis
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General Information
AccessionDCA00023559
TitleSmall molecules which mimic AIRE KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AIRE KO in the thymic epithelial cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f15ce467bea600fb9b52
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:60
Cell Typethymic epithelial cells
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM47956, GSM48039, GSM48042
Perturbed SamplesGSM48038, GSM48041, GSM48044
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2515
Gene Expression Omnibus
Autoimmune regulator AIRE knockout effect on thymic epithelial cells
7
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