Small molecules which mimic LMNA Lmna Gly609Gly knock-in
Canned Analysis
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General Information
AccessionDCA00023635
TitleSmall molecules which mimic LMNA Lmna Gly609Gly knock-in
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by LMNA Lmna Gly609Gly knock-in in the Liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f3a0e467bea600fb9c4e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvmathur
CREEDS IDgene:642
Cell TypeLiver
Gene Symbol (human)LMNA
Gene Symbol (mouse)Lmna
Organismmouse
Perturbation TypeLmna Gly609Gly knock-in
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM808406, GSM808407, GSM808408
Perturbed SamplesGSM808403, GSM808404, GSM808405
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE32609
Gene Expression Omnibus
Lmna G609G knock-in model of Hutchinson-Gilford Progeria Syndrome: liver
12
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