Small molecules which reverse IRAK4 Deficiency
Canned Analysis
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General Information
AccessionDCA00023696
TitleSmall molecules which reverse IRAK4 Deficiency
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IRAK4 Deficiency in the Embryonic fibroblasts cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ff59e467bea600fba130
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:680
Cell TypeEmbryonic fibroblasts
Gene Symbol (human)IRAK4
Gene Symbol (mouse)Irak4
Organismmouse
Perturbation TypeDeficiency
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM155304, GSM156795
Perturbed SamplesGSM156800, GSM156801
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6789
Gene Expression Omnibus
IRAK-4 kinase deficient fibroblast response to IL-1: time course
7
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