Small molecules which mimic CHEK1 KD
Canned Analysis
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General Information
AccessionDCA00023707
TitleSmall molecules which mimic CHEK1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by CHEK1 KD in the MCF-10A cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f912e467bea600fb9e72
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorCopernicia
CREEDS IDgene:692
Cell TypeMCF-10A
Gene Symbol (human)CHEK1
Gene Symbol (mouse)Chek1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1311313, GSM1311314, GSM1311315
Perturbed SamplesGSM1311328, GSM1311329, GSM1311330
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE54268
Gene Expression Omnibus
Expression data of ATM, ATR, CHK1, CHK2, and 53BP1 shRNA knockdown and control shRNA in MCF-10A cells
70
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