Small molecules which reverse CHEK1 KD
Canned Analysis
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General Information
AccessionDCA00023720
TitleSmall molecules which reverse CHEK1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CHEK1 KD in the U2OS cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f8e8e467bea600fb9e60
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorCopernicia
CREEDS IDgene:698
Cell TypeU2OS
Gene Symbol (human)CHEK1
Gene Symbol (mouse)Chek1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1311301, GSM1311302, GSM1311303
Perturbed SamplesGSM1311304, GSM1311305, GSM1311306
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54267
Gene Expression Omnibus
Expression data of CHK1 shRNA knockdown and control shRNA in U2OS cells
14
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