Small molecules which mimic SIRT1 KO
Canned Analysis
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General Information
AccessionDCA00023723
TitleSmall molecules which mimic SIRT1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SIRT1 KO in the brain cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22babe467bea600fbb480
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvirginia
CREEDS IDgene:70
Cell Typebrain
Gene Symbol (human)SIRT1
Gene Symbol (mouse)Sirt1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM712797, GSM712799, GSM712801, GSM712803
Perturbed SamplesGSM712769, GSM712798, GSM712800, GSM712802
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28790
Gene Expression Omnibus
SIRT1 deficiency effect on the brain
7
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