Small molecules which reverse GATA4 Deletion - for the second exon
Canned Analysis
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General Information
AccessionDCA00023748
TitleSmall molecules which reverse GATA4 Deletion - for the second exon
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by GATA4 Deletion - for the second exon in the Heart ventricles (of GATA4 animals heterozygous) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22d03e467bea600fbb51a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:739
Cell TypeHeart ventricles (of GATA4 animals heterozygous)
Gene Symbol (human)GATA4
Gene Symbol (mouse)Gata4
Organismmouse
Perturbation TypeDeletion - for the second exon
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM126895, GSM126898, GSM126901, GSM126902
Perturbed SamplesGSM126909, GSM126910, GSM126911, GSM126912, GSM126913
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5500
Gene Expression Omnibus
Gata4 heterozygous mutant heart response to pressure overload
14
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