Small molecules which reverse MYC Activation - 21 days
Canned Analysis
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General Information
AccessionDCA00023772
TitleSmall molecules which reverse MYC Activation - 21 days
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MYC Activation - 21 days in the Pancreatic islet beta cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22228e467bea600fbb04e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:754
Cell TypePancreatic islet beta cells
Gene Symbol (human)MYC
Gene Symbol (mouse)Myc
Organismmouse
Perturbation TypeActivation - 21 days
None{u'vals': [-0.105755850942, 0.0976552772562, -0.0952054774655, -0.0901207576141, 0.0753295185473, 0.0648523112601, -0.0622297030055, -0.0604353576259, 0.0589017551321, -0.0562807291119, 0.0561927157097, -0.0556139214511, -0.0554988043712, -0.0548687287373
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM99043, GSM99044, GSM99045
Perturbed SamplesGSM99058, GSM99059, GSM99060
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE4356
Gene Expression Omnibus
Myc activation and deactivation effect on pancreatic islet beta cells
35
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