Small molecules which mimic OTX2 KO
Canned Analysis
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General Information
AccessionDCA00023781
TitleSmall molecules which mimic OTX2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by OTX2 KO in the brain (fourth ventricular choroid plexus, E13) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22bf2e467bea600fbb4a0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcarlfulp
CREEDS IDgene:78
Cell Typebrain (fourth ventricular choroid plexus, E13)
Gene Symbol (human)OTX2
Gene Symbol (mouse)Otx2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM684731, GSM684732, GSM684733, GSM684734
Perturbed SamplesGSM684727, GSM684728, GSM684729, GSM684730
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE27630
Gene Expression Omnibus
Transcription factor Otx2 knockout effect on fourth ventricular choroid plexus
7
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