Small molecules which reverse SOD1 G93A mutation
Canned Analysis
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General Information
AccessionDCA00023850
TitleSmall molecules which reverse SOD1 G93A mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by SOD1 G93A mutation in the Spinal Cord Motor Neurons 120 day cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20397e467bea600fba312
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcms
CREEDS IDgene:847
Cell TypeSpinal Cord Motor Neurons 120 day
Gene Symbol (human)SOD1
Gene Symbol (mouse)Sod1
Organismmouse
Perturbation TypeG93A mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM277573, GSM277574, GSM277575
Perturbed SamplesGSM277570, GSM277571, GSM277572
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE10953
Gene Expression Omnibus
Amyotrophic lateral sclerosis model
24
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