Small molecules which reverse BRAF Drug inhibition
Canned Analysis
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General Information
AccessionDCA00023894
TitleSmall molecules which reverse BRAF Drug inhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by BRAF Drug inhibition in the A375 melanoma cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f618e467bea600fb9d60
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormauroccm
CREEDS IDgene:883
Cell TypeA375 melanoma cells
Gene Symbol (human)BRAF
Gene Symbol (mouse)Braf
Organismhuman
Perturbation TypeDrug inhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1052615, GSM1052616, GSM1052617
Perturbed SamplesGSM1052618, GSM1052619, GSM1052620
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42872
Gene Expression Omnibus
Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition
12
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