Small molecules which reverse FOXP3 ABLATION
Canned Analysis
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General Information
AccessionDCA00023942
TitleSmall molecules which reverse FOXP3 ABLATION
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by FOXP3 ABLATION in the mature regulatory T cells (Treg) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2141de467bea600fbaa56
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:91
Cell Typemature regulatory T cells (Treg)
Gene Symbol (human)FOXP3
Gene Symbol (mouse)Foxp3
Organismmouse
Perturbation Type ABLATION
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM154369, GSM154373
Perturbed SamplesGSM154366, GSM154371
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE6681
Gene Expression Omnibus
Foxp3 ablation effect on mature regulatory T cells
7
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