Small molecules which mimic PMP22 Trembler PMP22 point mutation
Canned Analysis
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General Information
AccessionDCA00023989
TitleSmall molecules which mimic PMP22 Trembler PMP22 point mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PMP22 Trembler PMP22 point mutation in the sciatic nerve, at PND 60 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20864e467bea600fba52c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:946
Cell Typesciatic nerve, at PND 60
Gene Symbol (human)PMP22
Gene Symbol (mouse)Pmp22
Organismmouse
Perturbation TypeTrembler PMP22 point mutation
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM34801, GSM34802, GSM34803
Perturbed SamplesGSM34817, GSM34818
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1947
Gene Expression Omnibus
Peripheral myelin protein 22 gene dosage and point mutation effect on sciatic nerve
63
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