Small molecules which mimic CFTR KO
Canned Analysis
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General Information
AccessionDCA00024007
TitleSmall molecules which mimic CFTR KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by CFTR KO in the Intestine cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21970e467bea600fbacac
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorshvetank
CREEDS IDgene:978
Cell TypeIntestine
Gene Symbol (human)CFTR
Gene Symbol (mouse)Cftr
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM133479, GSM133480
Perturbed SamplesGSM133466, GSM133467, GSM133468, GSM133469, GSM133470, GSM133476, GSM133477, GSM133478
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5715
Gene Expression Omnibus
Intestinal Phenotype of Variable Weight Cystic Fibrosis Knockout Mice
7
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