Enrichment analysis of genes dysregulated in IRF4 KO
Canned Analysis
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General Information
AccessionDCA00024520
TitleEnrichment analysis of genes dysregulated in IRF4 KO
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between IRF4 KO cells and control cells in the aïve T- cells isolated from spleen were cultured on a-CD3 coated plates with 2.5 mg/ml a-CD28, 20 ng/ml IL-6, 20 ng/ml IL-23, 1 ng/ml hTGFb, 10 mg/ml a-IL4 and 10 mg/ml a-IFNg for 42 hrs cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3092916
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1527
Cell Typeaïve T- cells isolated from spleen were cultured on a-CD3 coated plates with 2.5 mg/ml a-CD28, 20 ng/ml IL-6, 20 ng/ml IL-23, 1 ng/ml hTGFb, 10 mg/ml a-IL4 and 10 mg/ml a-IFNg for 42 hrs
Gene Symbol (human)IRF4
Gene Symbol (mouse)Irf4
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Control SamplesGSM999797, GSM999798, GSM999799
Perturbed SamplesGSM999794, GSM999795, GSM999796
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Datasets used in the analysis
Keyword
Tool Name
GSE40726
Gene Expression Omnibus
Transcriptional profiling of IRF4 -/- vs IRF4 +/- T-cells under Th17 polarizing conditions
7
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