Enrichment analysis of genes dysregulated in ITK KO
Canned Analysis
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General Information
AccessionDCA00024549
TitleEnrichment analysis of genes dysregulated in ITK KO
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between ITK KO cells and control cells in the unstimulated CD3+ T-cells (pooled thymus and spleen) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3095330
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1554
Cell Typeunstimulated CD3+ T-cells (pooled thymus and spleen)
Gene Symbol (human)ITK
Gene Symbol (mouse)Itk
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Control SamplesGSM313166, GSM313167, GSM313168
Perturbed SamplesGSM313169, GSM313170
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12466
Gene Expression Omnibus
Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells
7
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