Enrichment analysis of genes dysregulated in IL6 anti-IL6 monoclonal antibody, neutralization
Canned Analysis
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General Information
AccessionDCA00024550
TitleEnrichment analysis of genes dysregulated in IL6 anti-IL6 monoclonal antibody, neutralization
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between IL6 anti-IL6 monoclonal antibody, neutralization cells and control cells in the Xenograft tumors from DU145 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3096323
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1555
Cell TypeXenograft tumors from DU145
Gene Symbol (human)IL6
Gene Symbol (mouse)Il6
Organismhuman
Perturbation Typeanti-IL6 monoclonal antibody, neutralization
Characteristic Direction parameters
Control SamplesGSM1536778, GSM1536779, GSM1536780
Perturbed SamplesGSM1536775, GSM1536776, GSM1536777
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE62941
Gene Expression Omnibus
Inhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
21
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