Enrichment analysis of genes dysregulated in IL6 anti-IL6 monoclonal antibody, neutralization
Canned Analysis
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General Information
AccessionDCA00024551
TitleEnrichment analysis of genes dysregulated in IL6 anti-IL6 monoclonal antibody, neutralization
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between IL6 anti-IL6 monoclonal antibody, neutralization cells and control cells in the Xenograft tumors from NCI-H1650 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3096320
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1556
Cell TypeXenograft tumors from NCI-H1650
Gene Symbol (human)IL6
Gene Symbol (mouse)Il6
Organismhuman
Perturbation Typeanti-IL6 monoclonal antibody, neutralization
Characteristic Direction parameters
Control SamplesGSM1536784, GSM1536785, GSM1536786
Perturbed SamplesGSM1536781, GSM1536782, GSM1536783
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE62941
Gene Expression Omnibus
Inhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
21
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