Enrichment analysis of genes dysregulated in CCND1 KD
Canned Analysis
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General Information
AccessionDCA00025032
TitleEnrichment analysis of genes dysregulated in CCND1 KD
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between CCND1 KD cells and control cells in the MCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Estradiol treated cells were maintained for a further 24 hrs and then processed. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3094238
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2207
Cell TypeMCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Estradiol treated cells were maintained for a further 24 hrs and then processed.
Gene Symbol (human)CCND1
Gene Symbol (mouse)Ccnd1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Control SamplesGSM1191288, GSM1191289
Perturbed SamplesGSM1191292, GSM1191293
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48989
Gene Expression Omnibus
Cyclin D1 determines estrogen dependent signaling in human breast cancer cell line MCF7
14
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