Enrichment analysis of genes dysregulated in CTLA4 KO
Canned Analysis
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General Information
AccessionDCA00025201
TitleEnrichment analysis of genes dysregulated in CTLA4 KO
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between CTLA4 KO cells and control cells in the T cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3092230
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2400
Cell TypeT cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction.
Gene Symbol (human)CTLA4
Gene Symbol (mouse)Ctla4
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Control SamplesGSM921632, GSM921633, GSM921634
Perturbed SamplesGSM921635, GSM921636, GSM921637
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37563
Gene Expression Omnibus
In vivo gene expression data from wild type and CTLA-4 KO 5C.C7 T cells
7
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