Enrichment analysis of genes dysregulated in DOT1L DELETION
Canned Analysis
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General Information
AccessionDCA00025883
TitleEnrichment analysis of genes dysregulated in DOT1L DELETION
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between DOT1L DELETION cells and control cells in the AF9 - Mixed Lineage Leukemia (MLL) cells - 5 days cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3095781
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:454
Cell TypeAF9 - Mixed Lineage Leukemia (MLL) cells - 5 days
Gene Symbol (human)DOT1L
Gene Symbol (mouse)Dot1l
Organismmouse
Perturbation TypeDELETION
Characteristic Direction parameters
Control SamplesGSM636712, GSM636713, GSM636714, GSM636715, GSM636716
Perturbed SamplesGSM636707, GSM636708, GSM636709, GSM636710, GSM636711
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25911
Gene Expression Omnibus
Histone methyltransferase H3K79 Dot1l deletion effect on MLL-AF9 leukemia cells: time course
21
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