Enrichment analysis of genes downregulated following Lipopolysaccharide treatment
Canned Analysis
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General Information
AccessionDCA00055090
TitleEnrichment analysis of genes downregulated following Lipopolysaccharide treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Lipopolysaccharide treated cells and untreated control cells in the lung subsegment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bvsa
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdrug:2475
Cell Typelung subsegment
Drug NameLipopolysaccharide
Organismhuman
PubChem CID11970143
SMILES IDCCCCCCCCCCCCCCCC1C(OC(C(C1OC(=O)CC(CCCCCCCCCCC)O)O)COC2C(C(C(C(O2)COC3(CC(C(C(O3)C(CO)O)OC4C(C(C(C(O4)C(CO)O)OP(=O)(O)OP(=O)(O)OCCN)OC5C(C(C(C(O5)C(COC6C(C(C(CO6)(C(CO)O)O)O)O)O)OP(=O)(O)O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)OC9C(C(C(C(O9)CO)O)O)OC1C(
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM1004101, GSM1004103, GSM1004105, GSM1004107, GSM1004109, GSM1004111, GSM1004113
Perturbed SamplesGSM1004102, GSM1004104, GSM1004106, GSM1004108, GSM1004110, GSM1004112, GSM1004114
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40885
Gene Expression Omnibus
Alveolar macrophage response to bacterial endotoxin lipopolysaccharide exposure in vivo
7
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