Enrichment analysis of genes upregulated following Metformin treatment
Canned Analysis
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General Information
AccessionDCA00055105
TitleEnrichment analysis of genes upregulated following Metformin treatment
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Metformin treated cells and untreated control cells in the Human primary fibroblasts (IMR90) stably expressing H-RasV12 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1busq
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2483
Cell TypeHuman primary fibroblasts (IMR90) stably expressing H-RasV12
Drug NameMetformin
DrugBank IDDB00331
Organismhuman
PubChem CID4091
SMILES IDCN(C)C(=N)N=C(N)N
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM831051, GSM831052, GSM831053
Perturbed SamplesGSM831054, GSM831055, GSM831056
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE33612
Gene Expression Omnibus
Expression data from human primary fibroblasts (IMR90) stably expressing H-RasV12 and treated with Metformin or vehicle
7
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