Enrichment analysis of genes downregulated following Imatinib treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00055168
TitleEnrichment analysis of genes downregulated following Imatinib treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Imatinib treated cells and untreated control cells in the Chronic myelogenous leukemia CD34+CD38- cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1buwe
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2510
Cell TypeChronic myelogenous leukemia CD34+CD38- cells
Drug NameImatinib
DrugBank IDDB00619
Organismhuman
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM521987, GSM521991, GSM521995
Perturbed SamplesGSM521988, GSM521992, GSM521996
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20876
Gene Expression Omnibus
Chronic myelogenous leukemia CD34+CD38- cells response to histone deacetylase inhibitor analog and imatinib mesylate
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.