Enrichment analysis of genes downregulated following Olanzapine treatment
Canned Analysis
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General Information
AccessionDCA00055170
TitleEnrichment analysis of genes downregulated following Olanzapine treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Olanzapine treated cells and untreated control cells in the brain frontal cortex tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1buwb
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2511
Cell Typebrain frontal cortex tissue
Drug NameOlanzapine
Organismrat
PubChem CID4585
SMILES IDCC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM48559, GSM48577, GSM48578, GSM48579
Perturbed SamplesGSM48580, GSM48581, GSM48582, GSM48583
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2547
Gene Expression Omnibus
Antipsychotic agent olanzapine effect on the brain frontal cortex
7
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