Enrichment analysis of genes downregulated following Imatinib (glivec) treatment
Canned Analysis
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General Information
AccessionDCA00055174
TitleEnrichment analysis of genes downregulated following Imatinib (glivec) treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Imatinib (glivec) treated cells and untreated control cells in the Philadelphia chromosome positive CML CD34+ cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bvju
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2518
Cell TypePhiladelphia chromosome positive CML CD34+ cells
Drug NameImatinib (glivec)
Organismhuman
PubChem CID123596
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM307000, GSM307012, GSM307013, GSM307018, GSM307020, GSM307023
Perturbed SamplesGSM307028, GSM307030, GSM307031, GSM307032, GSM307053, GSM307072
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12211
Gene Expression Omnibus
Chronic myelogenous leukemia response to imatinib: Philadelphia chromosome positive CD34+ cells
7
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