Enrichment analysis of genes upregulated following Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00055179
TitleEnrichment analysis of genes upregulated following Imatinib treatment
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Imatinib treated cells and untreated control cells in the TAMs (tumor associated macrophages) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bvbz
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2522
Cell TypeTAMs (tumor associated macrophages)
Drug NameImatinib
DrugBank IDDB00619
Organismmouse
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM1250711, GSM1250712
Perturbed SamplesGSM1250713, GSM1250714
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE51698
Gene Expression Omnibus
The effect of imatinib therapy on tumor associated macrophages (TAMs) in murine gastrointestinal stromal tumor (GIST)
7
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