Enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
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General Information
AccessionDCA00055320
TitleEnrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells and untreated control cells in the cultured molar teeth from embryonic day 14 fetuses cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bunz
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdrug:2595
Cell Typecultured molar teeth from embryonic day 14 fetuses
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismmouse
PubChem CID15625
SMILES IDC1=C2C(=CC(=C1Cl)Cl)OC3=CC(=C(C=C3O2)Cl)Cl
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM109312, GSM109590
Perturbed SamplesGSM109592, GSM109593
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4873
Gene Expression Omnibus
2,3,7,8-tetrachlorodibenzo-p-dioxin effect on cultured embryonic teeth
7
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