Enrichment analysis of genes upregulated following Bortezomib treatment
Canned Analysis
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General Information
AccessionDCA00055501
TitleEnrichment analysis of genes upregulated following Bortezomib treatment
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Bortezomib treated cells and untreated control cells.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bvse
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2686
Drug NameBortezomib
DrugBank IDDB00188
Organismhuman
SMILES IDCC(C[C@@H](B(O)O)NC(=O)[C@@H](NC(=O)c1cnccn1)Cc1ccccc1)C
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM766676, GSM766677, GSM766678
Perturbed SamplesGSM766682, GSM766683, GSM766684
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE30931
Gene Expression Omnibus
Proteasome inhibitor Bortezomib effect on MCF7 breast cancer cells
7
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