Enrichment analysis of genes upregulated following Doxorubicin treatment
Canned Analysis
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General Information
AccessionDCA00055551
TitleEnrichment analysis of genes upregulated following Doxorubicin treatment
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Doxorubicin treated cells and untreated control cells.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bv2e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2720
Drug NameDoxorubicin
DrugBank IDDB00997
Organismhuman
PubChem CID31703
SMILES IDCC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM325240, GSM325242, GSM325244, GSM325246, GSM325248, GSM325250, GSM325252, GSM325254, GSM325256, GSM325258, GSM325260, GSM325262, GSM325264, GSM325266, GSM325268, GSM325270, GSM325272, GSM325274, GSM325276
Perturbed SamplesGSM325241, GSM325243, GSM325245, GSM325247, GSM325249, GSM325251, GSM325253, GSM325255, GSM325257, GSM325259, GSM325261, GSM325263, GSM325265, GSM325267, GSM325269, GSM325271, GSM325273, GSM325275, GSM325277
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12972
Gene Expression Omnibus
Liposarcoma response to doxorubicin in vitro
7
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