Enrichment analysis of genes downregulated following Anastrozole treatment
Canned Analysis
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General Information
AccessionDCA00055808
TitleEnrichment analysis of genes downregulated following Anastrozole treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Anastrozole treated cells and untreated control cells in the Breast Cancer tumor core biopsies cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bvoh
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvcogliani
CREEDS IDdrug:3087
Cell TypeBreast Cancer tumor core biopsies
Drug NameAnastrozole
DrugBank IDDB01217
Organismhuman
PubChem CID2187
SMILES IDCC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM832390, GSM832392, GSM832394, GSM832396, GSM832398, GSM832400, GSM832402, GSM832404, GSM832406, GSM832408, GSM832410
Perturbed SamplesGSM832391, GSM832393, GSM832395, GSM832397, GSM832399, GSM832401, GSM832403, GSM832405, GSM832407, GSM832409, GSM832411
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE33658
Gene Expression Omnibus
Anastrozole/Fulvestrant/Gefitinib neoadjuvant therapy of estrogen receptor positive breast cancer patients: tumor core biopsies
7
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