Enrichment analysis of genes downregulated following Metformin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00056184
TitleEnrichment analysis of genes downregulated following Metformin treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Metformin treated cells and untreated control cells in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bv07
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3308
Cell Typeliver
Drug NameMetformin
DrugBank IDDB00331
Organismmouse
PubChem CID4091
SMILES IDCN(C)C(=N)N=C(N)N
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM878116, GSM878117, GSM878118, GSM878119, GSM878120, GSM878121, GSM878122, GSM878123
Perturbed SamplesGSM878124, GSM878125, GSM878126, GSM878127
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE35961
Gene Expression Omnibus
Liver response to a metformin supplemented high fat diet deficient in methionine and choline
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.